Material Transfer Agreement form to be filed with requests for plasmids etc || The lab's research interests focus on the structural biology complex dynamic systems. Major foci -- 1) protein domains in intracellular signal transduction, including SH2, SH3, kinase, phosphatase, PH domains, and many others and how natural ligands interact with them. Signaling disorders related to these domains lead to many disease states. 2) Dynamic processes associated with nuclear transport. 3) An additional area of interest is the development of NMR and related methods for structural biology. Developmental projects include segmental labeling, other novel isotopic labeling methods, novel use of molecular dynamics simulation, small angle scattering by X-rays and neutrons, and detection of protein-protein interaction surfaces and dynamics.