Laboratory of David Cowburn

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NYSBC Material Transfer Agreement form to be filed with requests for plasmids etc 		The lab's research interests focus on the structural biology of protein domains in intracellular signal transduction, including SH2, SH3, kinase, phosphatase, PH domains, and many others and how natural ligands interact with them. Signaling disorders related to these domains lead to many disease states. An additional area of interest is the development of NMR and related methods for structural biology. Projects include segmental labeling, other novel isotopic labeling methods, and detection of protein-protein interaction surfaces and dynamics. Congratulations to Dongsheng and Ronnie -
Liu, D., Xu, R., and Cowburn, D. (2009). Segmental isotopic labeling of proteins for nuclear magnetic resonance. Methods Enzymol 462, 151-175.
Congratulations to Andrea -
Piserchio, A., Ghose, R., and Cowburn, D. (2009). Optimized bacterial expression and purification of the c-Src catalytic domain for solution NMR studies. J Biomol NMR 44, 87-93.
Graduate Programs Selected Publications Gallery
Seminars
• Cornell Biochemistry, including Tri Institutional Structural Biology Series
• NYSBC Meta - Group Meetings 		Ferrage F., Cowburn D., Ghose R. Accurate Sampling of High-Frequency Motions in Proteins by Steady-State (15)N-{(1)H} Nuclear Overhauser Effect Measurements in the Presence of Cross-Correlated Relaxation. J Am Chem Soc 2009 May 6; 131 (17):6048-9
Xiong X, Cui P, Hossain S, Xu R, Warner B, Guo X, An X, Debnath A, Cowburn D, Kotula L. (2008) . Allosteric Inhibition of the nonMyristoylated c-Abl Tyrosine Kinase by Phosphopeptides Derived from Abi1/Hssh3bp1. BBA Molecular Cell Research, 1783, 737-47.
Bhattacharya S, Zhang H, Debnath AK, Cowburn D. (2008) Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid. J Biol Chem, 283, 16274-8. 		Link

David Cowburn, Ph.D., D.Sc., President and CEO, New York Structural Biology Center, Head, Lab. Physical Biochemistry; 89 Convent Ave., New York, NY, 10027-7556, USA. T: +1 212 939 0660 x 9 115#; F: +1 212 208 2597; cowburn@cowburnlab.org.