Laboratory of David Cowburn

Home Lab Members Publications Our Associations Directions and Maps Local News

Resources What we do News
Material Transfer Agreement form to be filed with requests for plasmids etc The lab's research interests focus on the structural biology of protein domains in intracellular signal transduction, including SH2, SH3, kinase, phosphatase, PH domains, and many others and how natural ligands interact with them. Signaling disorders related to these domains lead to many disease states. An additional area of interest is the development of NMR and related methods for structural biology. Projects include segmental labeling, other novel isotopic labeling methods, and detection of protein-protein interaction surfaces and dynamics. Congratulations to Dongsheng and Ronnie -
Liu, D., Xu, R., and Cowburn, D. (2009). Segmental isotopic labeling of proteins for nuclear magnetic resonance. Methods Enzymol 462, 151-175.

Congratulations to Fabien, Alex, and Kaushik -- 2010 Structural determination of biomolecular interfaces by nuclear magnetic resonance of proteins with reduced proton density. J Biomol NMR .
Graduate Programs Selected Publications Gallery
Seminars
Cornell Biochemistry, including Tri Institutional Structural Biology Series
NYSBC Meta - Group Meetings
Ferrage F., Cowburn D., Ghose R. Accurate Sampling of High-Frequency Motions in Proteins by Steady-State (15)N-{(1)H} Nuclear Overhauser Effect Measurements in the Presence of Cross-Correlated Relaxation. J Am Chem Soc 2009 May 6; 131 (17):6048-9
Xiong X, Cui P, Hossain S, Xu R, Warner B, Guo X, An X, Debnath A, Cowburn D, Kotula L. (2008) . Allosteric Inhibition of the nonMyristoylated c-Abl Tyrosine Kinase by Phosphopeptides Derived from Abi1/Hssh3bp1. BBA Molecular Cell Research, 1783, 737-47.
Bhattacharya S, Dai Z, Li J, Baxter S, Callaway DJ, Cowburn D, Bu Z. A conformational switch in the scaffolding protein NHERF1 controls autoinhibition and complex formation. J Biol Chem. 2010 ;285(13):9981-94
Link


Other links - Research Cross Roads Faculty of 1000 Linked In Scientific Commons Biomed Experts
Publications at Rockefeller University Google Scholar Next Bio Science Storm Sci Link DC Full Bio

David Cowburn, Ph.D., D.Sc., President and CEO, New York Structural Biology Center, Head, Lab. Physical Biochemistry; 89 Convent Ave., New York, NY, 10027-7556, USA. T: +1 212 939 0660 x 9 115#; F: +1 212 208 2597; cowburn@cowburnlab.org.