List of participating research groups
Summer Meeting 2013, Mount Sinai School of Medicine (#69)
Original pictures from Samuel Sparks
The conveners thanks the Mount Sinai School of Medicine and Iban Ubarretxena for the outstanding real estate. The New York Structural Biology Center, the New York Academy of Sciences, and Cold Spring Harbor Laboratory provided infrastructural support.
- Moshe Dessau, Yale University, "Crystal structure of glycoprotein C from Rift Valley Fever virus"
- Cheng-Tsung Lai, Stony Brook University, "Structural mechanism for the slow-onset inhibition of mycobacterium tuberculosis inha "
- Weifeng Liu, Albert Einstein College of Medicine, "Exploration and blockade of decoy strategy: crystal structure of the light:Dcr3 complex and rational design of Dcr3 antagonists"
2013 Winter Meeting, New York Academy of Science (#68)
Aneel Aggarwal, Mount Sinai School of Medicine
"DNA - Protein Recognition : Engineering New Specificity"
Karim-Jean Armache, NYU Med
"Structural characterization of silent chromatin"
Grégory Boël, Columbia University (Hunt Lab)
"Structural biology powering discovery biology: elucidation of the physiological function and molecular mechanism of a novel family of translation factors that regulate commitment of energetic resources to protein synthesis"
Elizabeth Campbell, Rockefeller University (Darst Lab)
"Structure and function of Car D, an essential Mycobacterial transcription factor"
Andras Fiser, Albert Einstein College of Medicine
"Modeling proteins using a super-secondary structure library and NMR chemical shift information"
Charalampos (Babis) Kalodimos, Rutgers
"Recognition of unfolded proteins by molecular chaperones"
Steve Long, Memorial Sloan Kettering Cancer Center
"Crystal structure of the calcium release-activated calcium channel Orai"
Filippo Mancia, Columbia University
"Crystal structure of sulfate transporter CysZ"
Ivo Melčák, Rockefeller University (Blobel Lab)
"Architecture of the Transport Channel of the Nuclear Pore Complex"
Greg Petsko, Weill Cornell
"The Structural Biology of Parkinson's Disease"
Alexandros Pertsinidis, Memorial Sloan Kettering Cancer Center
"Sub-diffraction fluorescence imaging of molecular structures and interactions"
Deniz Temel, City College of New York (Ghose Lab) 1
"Regulatory Interactions between a Bacterial Tyrosine Kinase and its Cognate Phosphatase"
Outstanding Poster Awards
Prizes supported by the Suraj P. Manrao Science Foundation, and Nature Structural and Molecular Biology
Pictures from Winter Meeting 2013
2012 Summer Meeting, Weill Cornell Medical College (#67)
Prof. Steven Almo, Albert Einstein College of Medicine of Yeshiva University
"From PDBs to Pathways"
Prof. David Fushman, Dept. of Chemistry and Biochemistry, U. Maryland
'Deciphering the "ubiquitin" code.'
Prof. David Jeruzalmi, Dept. of Chemistry, CCNY and Molecular and Cellular Biology, Harvard University
"Inner workings of the UvrA-UvrB DNA damage sensor"
Prof. Wayne Hendrickson, Columbia University
"Multi-crystal native SAD structures routinely from light-atom anomalous diffraction"
Dr. Nathan Karpowich, NYU (Wang lab)
"Structure and Assembly of an ECF Transporter for Riboflavin"
Prof. Themis Lazaridis, CCNY, CUNY
"Modeling protein-membrane interactions"
Dr. David LeMaster, Wadsworth Center, Albany
"Rotational Velocity Rescaling of Molecular Dynamics Trajectories for Direct Prediction of Protein NMR Relaxation"
Prof. Michael Rout, Rockefeller University
"The Hole Picture? Architecture and Mechanism of the Nuclear Pore Complex"
Dr. Yibing Shan, D.E. Shaw Research,
"Models of full-length EGF receptors and the effects of the oncogenic cancer mutations"
Kate Stafford, Columbia U (Palmer lab)
"Exploring the conformational dynamics of ribonuclease H by integration of molecular dynamics simulations and NMR spectroscopy"
Prof. Iban Ubarretxena-Belandia, Mount Sinai School of Medicine
"Electron microscopy structure of Leucine Rich Repeat Kinase 2 involved in Parkinson disease"
Prof. Hao Wu, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
"Oligomeric signalosomes in TLR and TNFR pathways - a new concept in signaling?"
Illustration 1: Presenters – Michael Rout, Steven Almo, Yibing Shan, Iban Ubarretxena-Belandia, David Jeruzalmi, Nathan Karpowich ;
(below) Hao Wu, David Fushman, Kate Stafford, Themis Lazaradis, David LeMaster, & Wayne Hendrickson
Illustration 2: Poster Awardees, presented by Suraj Manrao. Romina Mancusso (with G. Glenn Gergorio, Qun Liu, and Da-Nang Wang -- NYU Med) "Structure and Mechanism of a bacterial sodium-dependent dicarboxlate transporter" : Yu Zhang (Rutgers) "Structural basis of transcription initiation" : Yogesh Gupta (with Aneel Aggarwal, MSSM) "Structural insights into the assembly and shape of type III restriction - modification EcoP151 complex by SAXS"
2012 Winter Meeting, New York Academy of Science (#66)
Scott Blanchard, Weill Cornell Medical College; Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding
Poster awardees (and their prizes!) :
Eric Greene, Columbia University Rinku Jain (Aggarwal Lab) Mount Sinai School of Medicine Wei-Li Liu, Einstein College of Medicine Ming-Ming Zhou, Mount Sinai School of Medicine Joel Butterwick (MacKinnon Lab), Rockefeller University Steven Ealick, Cornell University John Hunt, Columbia University Michael Ward, New York University David Case, Rutgers University Andisheh Abedini (Schmidt Lab), New York University School of Medicine David E. Shaw, D.E. Shaw Research Noel Carrascal, Stony Brook University Jaehyun Cho, Columbia University Tanvir Shaikh, Wadsworth Center
Speakers & Chairs from 2012 Summer Meeting at New York Academy of Science
(L->R) Wolfgang Peti, Anthony Armstrong, Robert Sweet, Burce Ergel, Liang Tong, Tali Lavy, David Stokes, Ken Dill, David Eliezer, Ming Zhou, David Cowburn
(not shown, Tarun Kapoor, Helen Berman, Hiro Furikawa, Chris Sander)
Poster awardees (and one of their prizes!) : Sozanne R. Solmaz (Rockefeller U.),
Paul Robustelli (Columbia U.), Breann C. Brown (Brown U.).
Poster awards from Nature Structural and Molecular Biology.
2011 Summer Meeting, Cold Spring Harbor Laboratory, 2011 (#65)
Paul Driscoll, University College London; Tracking death domain complex assembly with NMR
Qing Fan, Columbia University; Structural studies of human GABA(B) receptor
Evripidis Gavathiotis, Albert Einstein College of Medicine; Tracing a Killer's Path: Structural insights into the Activation Pathway of Pro-Apoptotic BAX
Wayne Hendrickson, Columbia University; Structural Analysis of SLAC1-family Anion Channel Activity
Gaetano Montelione, Rutgers University; Structural Biology of the Human Cancer Protein Interaction Network
Vivek Patel, Albert Einstein College of Medicine (Singer lab); Conserved RNA recognition element identifies ZBP1-operated post-transcriptional regulatory networks
Thomas Schalch, Cold Spring Harbor Lab (Joshua-Tor lab); Coupling RNAi to Heterochromatin: Insights into the Structure of the RITS Complex
Alexander Shekhtman, SUNY at Albany; Signal transduction in RAGE: structural biology of the receptor for advanced glycation end products
Jikui Song, Sloan-Kettering Institute (Patel lab); DNMT1 and maintenance DNA methylation
Yinghao Wu, Columbia University (Honig lab); Multiscale simulation of cadherin-mediated cell adhesion
Sponsored Lunchtime presentation -- Brian Lang, GE; Using SPR to study interactions of membrane proteins
Speakers & Chairs from 2011 Summer Meeting at Cold Spring Harbor
Laboratory
(L->R) David Cowburn, Thomas Schalch, Yinghao Wu, Evripidis Gavathiotis, Alexander Shekhtman, Qing Fan, Gaetano Monterione, Colin Driscoll, Ruth Stark, Wayne Hendrickson, Vivek Patel, Hao Wu, Jikui Song. Missing, Scott Blanchard.
Guozhou Xu, Weill Cornell Medical College, Structure, Substrate Specificity and Mechanism of Kinase Activation of the IkB Kinase β (IKKβ);
Kotaro Nakanishi, MSKCC;Structural basis for double-stranded RNA processing and insights into the catalytic mechanism and evolution of a non-canonical Dicer.
Qiangfeng Cliff Zhang, Columbia Univ. Towards the integration of structural and systems biology:
structure-based studies of protein-protein interactions on a genome-wide scale
Special award of NSMB subscription: Jennifer Hackett (Dalton School), Steven Mason (NSMB)
2011 Winter Meeting, New York Academy of Sciences, January 19, 2011
High-throughput Single Molecule Imaging of Protein-DNA Interactions
SAXS Analysis of DNA Polymerase Delta
Nanoscale Probing of the Tumor Suppression Transcription
Initiation Machinery
Learning the Chromatin Language of Gene Expression
Solution Structure and Phospholipid Interactions of the Isolated
Voltage Sensor Domain from KvAP
ThiC and Dph2: Two Unpredicted Radical SAM Enzymes
A Rational Approach to Engineering Improved Protein
Crystallization
Crystal Growth Inhibitors for the Prevention of L-Cystine Kidney
Stones through Molecular Design
Testing Biomolecular Force Fields against Crystal and NMR Data
Toxic Intermediates during IAPP Amyloid Formation
Millisecond-Long Molecular Dynamics Simulations of Proteins on
a Special-Purpose MachineAward Winning Posters
Prediction of side-chain conformations at the protein-DNA interface
Tuning Protein Autoinhibition by Domain Destabilization
Association of Ribosomal Subunits As Studied By Time-Resolved Cryo-Electron Microscopy
Poster Award Winners (left to right): Noel Carrascal, Jaehyun Cho, Tanvir Shaikh
Speakers & Chairs from 2011 Winter Meeting at the New York Academy of Sciences
left to right: David Stokes, David Cowburn, Rinku Jain, Wei-Li Liu, David Case, Eric Greene, Joel Butterwick,
Steven Ealick, Andisheh Abedini, David Eliezer, Ming-Ming Zhou, Michael Ward, John Hunt, David Shaw, Hao Wu
2010 Summer Meeting, Cold Spring Harbor Laboratory, August 4, 2010
Nicolas Nassar, Stony Brook University
Structural, functional & mechanistic insights into the Sts family of phophatases
Pravin Nair (Shuman Lab), Sloan Kettering Cancer Center
LigD 3’-phosphoesterase structure unveils a new superfamily for DNA repair
John Blanchard, Einstein College of Medicine
Targets in tuberculosis
Yossi Schlessinger, Yale University
Guozhou Chen (Hughson lab), Princeton University
Disrupting quorum sensing: mechanism underlying antagonist function
Hao Wu, Weill Cornell Medical College
Elegant mechanisms of death domain assembly in apoptosis and immunity
Bob Sweet, Brookhaven National Lab
Essence of NSLSII for structural biologists
Jonathan Javitch, Columbia University
Single-molecule dynamics of gating in a neurotransmitter transporter
Jae-Hyun Cho (Palmer Lab), Columbia University
Tuning Protein Autoinhibition by Domain Destabilzation
Ann McDermott, Columbia University
Enzyme Motions: Studies by Solid State NMR
Ming Zhou, Columbia University
Crystal Structure of Bacterial Potassium Ion Transporter TrkH
Kehui Xiang (Tong Lab), Columbia University
Structure of symplekin-Ssu-72-CTD phosphopeptide complex and
implications for pre-mRNA polyadenylation
Chris Lima, Sloan Kettering Cancer Center
Structure and function in the SUMO pathway
Selected Speakers & Chairs from 2010 Summer Meeting at Cold Spring Harbor Laboratory
2010 Winter Meeting, New York Academy of Sciences, January 13, 2010
Alessio Accardi, Weill Cornell Medical College
Molecular basis of ion binding & selectivity in CLC transporters and channels
Mark Ptashne, Sloan Kettering Cancer Institute
Effect of RSC/nucleosome complex on chromatin architecture and
expression of the GAL genes of yeast
Wayne Hendrickson, Columbia University
Signal transmission through the TMAO-responsive histidine kinase
Vern Schramm, Einstein College of Medicine
Enzymatic transition states in drug design
Sebastian Doniach
What can SAXS tell us about conformational changes in small functional RNAs
Ted Scovell, NYC SMART Team
Get SMART: Using physical models to teach protein structure
Moosa Mohammadi, NYU School of Medicine
Molecular basis for FGF receptor autoinhibition
Xin-Yun Huang, Weill Cornell Medical College
Structural basis for migrastatin analogues targeting fascin to inhibit
tumor metastasis
Da-Neng Wang, NYU School of Medicine
Structure and mechanism of a pentameric formate channel from Vibrio cholerae
Axel Innis (Steitz Lab), Yale University
Regulatory nascent peptides and the ribosome
Seth Darst, Rockefeller University
Structural basis for Pribnow box recognition by the bacterial RNA
polymerase sigma subunit
Award Winning Posters
Peng Liu, Columbia University
Prediction of side-chain conformations at the protein-DNA interface
Nicolas Reyes, Weill Cornell Medical College
Transport mechanism of a prokaryotic homology of glutamate transporters
Deborah Stoner-Ma, Brookhaven National Lab
Correlated single crystal spectroscopy and macromolecular X-ray crystallography
at beamline X26-C of the NSLS
Lee Tremblay, Einstein College of Medicine
The structure-based design of novel inhibitors of Mycobacterium tuberculosis
b-lactamase as chemotherapeutic agents
Sean West, Columbia University
Minor groove electrostatics provides a molecular origin for protein-DNA specificity
Poster Award Winners (left to right): presented by Boyana Konforti (Nature Struct & Molec Biol), Sean West (Columbia)
Peng Liu (Columbia), Nicolas Reyes (Cornell), Deborah Stoner-Ma (Brookhaven), Lee Tremblay (Einstein),
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2009 Summer Meeting, Cold Spring Harbor Laboratory, August 5, 2009
Olga Boudker, Weill Cornell Medical College
Alternating access mechanism of glutamate transporters
Elena Levin (Ming Zhou Lab), Columbia University
The 2.3 A crystal structure of a bacterial urea transporter
Liguo Wang (Fred Sigworth Lab), Yale University
Cryo-EM structure of the BK channel in a lipid membrane
Steve Smith, Stony Brook University
Multiple switches in the activation of the visual receptor rhodoopsin
Brian Loomis (Stephen Goff Lab), Columbia University
The Moloney Murine Leukemia Virus Pseudoknot: A pH-Dependent Riboswitch
Zimei Bu, Fox Chase Cancer Center
A conformational switch autoregulates the scaffolding protein NHERF1
Rebecca Page, Brown University
Using Structural Biology to Combat Antibiotic Resistance
Jae Hyun Bae (Joseph Schlessinger Lab), Yale University
Tyrosine kinase selectivity controlled by secondary SH2 binding site
Yi Ren (Fred Hughson Lab), Princeton University
Molecular Architecture of the Dsl1 Vesicle Tethering Complex
Elias Lolis, Yale University
Macrophage migration inhibitory factor from Ancylostoma ceylanicum
Jianping Zheng (Nadrian Seeman Lab), New York University
Design and Self-Assembly of 3D DNA Crystals
Remo Rohs (Barry Honig Lab), Columbia University
Role of DNA Shape in Protein-DNA Recognition
David Wah, Public Health Research Institute
C-terminal Domain of Transcription Factor IIB from Trypanosoma brucei
Selected Speakers & Chairs from 2009 Summer Meeting at Cold Spring Harbor Laboratory
Front row: Yi Ren, Ruth Stark, Jianing Zheng, Rebecca Page, Brian Loomis, Elena Levin
Second row: David Stokes, David Eliezer, Jae Hyun Bae, David Wah, Steve Smith, Hao Wu
Third row: Liguo Wang, Olga Boudker, Remo Rohs
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2009 Winter Meeting, New York Academy of Sciences, January 22, 2009
David Green, Stony Brook University
The structural glycobiology of HIV: Insights from computational models
Davide Provasi (Marta Filizola Lab), Mt. Sinai
Stimulating long timescale biological processes with metadynamics
Paramjit Arora, New York University
Synthetic approaches for targeting protein interfaces
Rajesh Kumar Prakash (Leemor Joshua-Tor Lab), Cold Springs Habor
Turning ON transcription: A sugary tale revisited
Ewa Folta-Stogniew, Yale University
Light scattering for analysis of oligomerization and protein interactions
Steve Hubbard, New York University
Structural basis for protein recruitment to the insulin receptor and muscle specific kinase
Vinzenz Unger, Yale University
Insights into the mechanisms of copper transport
David Borhani, DE Shaw Institute
Block or lock
Jin Kim Montclare, New York University
A. oryzae cutinase: Biocatalyst for synthetic ester and polyester degradation
David Gadsby, Rockefeller
The ion pathway through the Na,K-ATPase pump
Daniel Schmidt (MacKinnon Lab), Rockefeller
Turning Kv channel by the mechanical state of the lipid membrane
Crina Nimigean, Weill Cornell Medical
A novel mechanism of K channel selectivity revealed b ionic interactions within the pore
Selected Speakers & Chairs from 2009 Winter Meeting at the New York Academy of Sciences
David Gadsby, Crina Nimigean, David Eliezer, Hao Wu, Paramjit Arora, Ruth Stark, David Provasi
Jin Kim Montclare, David Green, Ewa Folta-Stogniew, Steve Hubbard, Rajesh Kumar Prakash, David Stokes, Vinzenz Unger
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2008 Summer Meeting, Cold Spring Harbor Laboratory August 6, 2008
Dax Fu, Biology, Brookhaven National Lab
Structure and mechanism of the zinc transporter YiiP
Chunyan Tang (Li Lab), Biology, Brookhaven National Lab
Fiber formation in bacteria by the Chaperone/Usher pathway
Robert Abel (Friesner Lab), Chemistry, Columbia University
The role of the solvent in protein-ligand binding and protein structure
Neer Asherie, Physics & Biology, Yeshiva University
Precipitant chirality and the crystallization of thaumatin
Agni Ghosh (Lima Lab), Structural Biology, Sloan Kettering Inst
Fcp1, the phosphatase required for RNAPII turnover
Dinshaw Patel, Structural Biology, Sloan Kettering Inst
Structure of Argonaute with bound guide strand and message
Marc Allaire, Beamline, Brookhaven National Lab
Discussion of X-ray data collection: stationary crystals - integrated spots
Wolfgang Peti, Mol Pharm, Physiol & Biotech, Brown
Structural basis for protein phosphatase 1 regulation
Richard Pomerantz (O'Donnell Lab), DNA Replication, Rockefeller
Mechanism of replisome bypass of a co-directional RNA polymerase
Eva Vanamee (Aggrawal Lab), Structural & Chemical Biol, Mt Sinai
DNA cutting molecular scissors: from bench to bedside
Allen Orville, Biology, Brookhaven National Lab
A fl avin-C4a-oxygen intermediate
Qian Yin (Wu Lab), Biochem & Struct Biol, Cornell Med College
Structural Basis of TRAF6-mediated Ubiquitination
Dario Ghersi (Sanchez Lab), Structural & Chemical Biol, Mt Sinai
Computational approaches to detect and exploit protein binding sites
Joachim Frank, Biochem & Mol Biophys, Columbia
The Ribosome: a molecular machine with intrinsic instability
Selected Speakers & Chairs from 2008 Summer Meeting at Cold Spring Harbor Laboratory
front: Hao Wu, Allen Orville, Agni Gosh, Chungyan Tang, Eva Vanamee, David Eliezer, Dario Ghersi
rear: Richard Pomeranz, David Stokes, Wolfgang Peti, Joachim Frank, Marc Allaire, Neer Asherie, David Cowburn, Robert Abel
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2008 Winter Meeting, Weil Cornell Medical College February 29, 2008
Yarden Opatowsky (Schlessinger Lab), Pharmacology, Yale Univ
Activation of receptor tyrosine kinase Kit by Stem Cell Factor
Carlos Escalante (Aggarwal Lab), Struct & Chem Biol, Mt. Sinai
Structural and functional studies of AAV Rep proteins
Matt Bick (Darst Lab), Molec Biophysics, Rockefeller University
How to switch off a histidine kinase: 2Ã… structure of KinB/Sda
Liang Tong, Columbia University
Structural Studies of Fatty Acid Metabolism and the Obesity Epidemic
Linda Nicholson, Physical Biochemistry, Cornell Univ
Pin1, a molecular timer in Alzheimer’s disease
Alex Shekhtman, Chemistry, SUNY Albany
In-vivo Biochemistry using NMR Spectroscopy
Charalampos Kalodimos, Chemistry, Rutgers Univ
Structural basis for assembly of large protein machineries by NMR
Da-Neng Wang, Struct Biol, NYU School of Medicine
LeuT-desipramine structure reveals how antidepressants work
Qinglian Liu (Hendrickson Lab), Biochem & Biophys, Columbia
Insights into Hsp70 chaperone from a structure of yeast Hsp110 Ssel
Holger Sondermann, Molecular Medicine, Cornell U
Regulation of the diguanylate cyclase response regulator WspR
James Love, NYCOMPS, NYSBC
High throuput membrane protein production at NYCOMPS
David Stokes, Struct Biol, NYU School of Medicine
Structure of an ATP-dependent copper pump by cryoEM
Michael Rout (Cellular and Struc Biol, Rockefeller Univ)
Structure, function and evolution of the nuclear pore complex
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2007 Summer Meeting, New York Academy of Sciences August 8, 2007
Erec Stebbins, Structural Microbiology, Rockefeller University
Structural Microbiology in Bacterial Pathogenesis
Jung-Hyun Min (Pavletich Lab), Structural Biology, Memorial Sloan Kettering Cancer Center
DNA-damage Recognition by Rad4 Nucleotide Excision Repair Protein
Hiro Furukawa, Cold Spring Har/<
Structure and Function of NMDA receptors
Iban Ubarretxena, Struct & Chem Biol, Mt. Sinai School of Medicine
Structural and Functional Studies of Intramembrane Proteases
Chunyu Wang, Biology, Rensselaer Polytechnic Institute
Aβ40 Protects Nontoxic Aβ42 Monomer from Aggregation
Fabien Ferrage, CNRS & NYSBC
The Nuclear Overhauser Effect for Protein Structure and Dynamics
Boris Reva (Sander Lab), Computational Biology, Memorial Sloan Kettering Cancer Center
Assessing the Functional Consequences of Protein Mutations in Cancer
Tonya Silkov, Pharmacology, Columbia University
Structural Analysis of ANTH-ENTH-VHS Superfamily
Richard Bonneau, Biology, New York University
The Human Proteome Folding Project: Can Rosetta de novo Contribute
to Genome Annotation?
Gino Cingolani, SUNY Upstate Medical University
Architecture of Viral Cell Envelope Penetration Device
Greg Boel (Hunt Lab), Biological Sciences, Columbia University
From Transmembrane Transport to Translational Regulation
Steve Soisson, Merck
Structural Basis for Inhibition of Fatty Acid Synthesis by Platensimycin
Wayne Hendrickson, Biochemistry & Biophysics, Columbia University
Structure-based Design of HIV Entry Inhibitors
Selected Speakers & Chairs from 2007 Summer Meeting at the New York Academy of Sciences
front: Richard Bonneau, Jung-Hyun Min, Chunyu Wang, Hao Wu, Fabien Ferrage
rear: Hiro Furukawa, Greg Boel, Steve Soisson, Charles Darwin, David Stokes, Wayne Hendrickson, David Eliezer
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2007 Winter Meeting, City College of New York, January 24, 2007
Tom Muir, Protein Chemistry, Rockefeller University
The Ins and Outs of K+ channels explored through synthesis
Jaclyn Greimann (Lima Lab), Structural Biology, Sloan Kettering Inst
The eukaryotic RNA exosome
Suvobrata Chakravarty (Zhou Lab), Mol. Physiol. & Biophys., Mt Sinai School of Medicine
Histone binding selectivity of bromodomains
Yingkai Zhang, Chemistry, New York University
Computer simulation of histone modifying enzymes
Juha Himanen (Nikolov Lab), Structural Biology, Sloan Kettering Institute
Eph receptor signaling
Alexei Soares, NSLS, Brookhaven National Laboratory
Automation program for macromolecular crystallography at NSLS
Ronald Koder, Physics, City College of New York
Oxygen binding & activation in a de novo designed hemoprotein
Erik Martinez-Hackert (Hendrickson's Lab), Biochemistry & Biophysics, Columbia
Recognition, folding & biogenesis by the chaperone trigger factor
Steve Almo, Physiology & Biophysics, Einstein College of Medicine
Stuctural biology of T-cell co-stimulation
Marc Allaire, NSLS, Brookhaven National Lab
Transient intermediates in the molecular machinery for nutrient uptake
Elena Yakubovskaya (Bogenhagen Lab), Pharmacology, SUNY Stony Brook
EM structure of human mitochondrial DNA poymerase
Larry Shapiro, Biochem. & Molec. Biophysics, Columbia
Cellular energy regulation by the AMP-activated protein kinase
Selected Speakers from 2007 Winter Meeting at CCNY
front: Steve Almo, Elena Yakubovskaya, Juha Himanen, Jaclyn Greimann
rear: Suvobrata Chakravarty, Alexei Soares, Marc Allaire
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2006 Summer Meeting, Cold Spring Harbor Laboratory, July 19, 2006
Ranajeet Ghose, Chemistry, City College of New York
A molecular anchor for intramembrane proteolysis
Ying Huang (Xu Lab), Skirball Inst, NYU School of Medicine
Structural mechanisms of histone code recognition
Jayakrishnan Nandakumar (Lima Lab), Structural Biology, Sloan Kettering
Structures of RNA ligase intermediates elucidate
the catalytic mechanism
Scott Blanchard, Physiol & Biophys, Weill Medical College
Imaging protein synthesis using single-molecule FRET
Filippo Mancia, Bioch & Mol Biophys, Columbia Univ
Asymmetry in dimeric associations of the serotonin 2c receptor
Andrew Stewart (Jacobsen Lab), Physics, Stony Brook University
Diffraction microscopy: will it lead to crystallography without crystals?
Julio Fernandez, Biology, Columbia Univ
Force-dependent activity of thioredoxin at the level of single disulfides
Ann McDermott, Chemistry, Columbia Univ
Solid state NMR studies of membrane associated proteins
Matt Vetting (Blanchard Lab), Biochem, Einstein College of Medicine
The pentapeptide repeat protein fold and fluoroquinolone resistance
Giovanna Scapin, Medicinal Chemistry, Merck
1st & 2nd generation DP-4 inhibitors for treatment of type 2 diabetes
Carlos Simmerling, Chemistry, Stony Brook University
Conformational dynamics of HIV-1 protease
Eric Enemark (Joshua-Tor lab), Struct Biology, Cold Spring Harbor Lab
DNA translocation by a replicative hexameric helicase
Dinshaw Patel, Structural Biology, Sloan Kettering Cancer Center
Structural biology of riboswitches and the histone code
Selected Speakers & Chairs from 2006 Summer Meeting at Cold Spring Harbor Laboratory
front: Hao Wu, Dinshaw Patel, Ying Huang, Leemor Joshua-Tor, Ronnie Ghose, Carlos Simmerling,
Giovanna Scapin, Julio Fernandez, Matt Vetting, David Stokes
rear: Wayne Hendrickson, Eric Enemark, Filippo Mancia, Anne McDermott, Jayakrishnan Nandakumar
seated: Andrew Stewart
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2006 Winter Meeting, Hunter College School for Health Sciences, January 24, 2006
Art Palmer, Biochem & Mol Biophys, Columbia Univ
Folding of the villin headpiece domain
Olga Boudker, Physiol & Biophys, Weill Med College
Structural insights into the
mechanism of glutamate transporters
Alex Kentsis (Osman Lab), Physiol & Biophys,
Mt. Sinai
Protein stability calculations using
Monte Carlo and graph manifold learning
Huilin Li, Biology, Brookhaven National Laboratory
A tale of two protease complexes
Diana Murray, Microbiol & Immun, Weill Med
College
PTEN and membrane re-organization: A
computational perspective
Yang Shen (Tong Lab), Biology,
Columbia University
Novel mechanism for inhibition of
acetyl-CoA carboxylase by soraphen A
Rod MacKinnon, Neurobiol & Biophys,
Rockefeller
Voltage dependent potassium channels
David Eliezer, Biochemistry, Weill Med College
Structural properties of the
Alzheimer’s disease protein tau
Bob Callender, Biochem, Einstein
College of Medicine
Contribution of atomic and molecular
motion to enzymatic catalysis
Deepak Nair (Aggarwal Lab), Physiol & Biophys,
Mt. Sinai
Structural basis of lesion bypass by
DNA polymerase iota and REV1
Marta Filizola, Physiol & Biophys, Weill Med
College
Structural models and dynamics of
GPCR oligomers
Richard Gillilan, MacCHESS, Cornell University
New opportunities with Cornell’s
Energy Recovery Linac
Kakoli Mitra (Frank Lab), Comp Biol & Mol
Imaging, Wadsworth Ctr
Structure of E. coli
protein-conducting channel bound to translating ribosome
Seth Darst, Molecular Biophys, Rockefeller
University
Structural basis for transcription-coupled DNA repair in bacteria
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2005 Summer Session, Cold Spring Harbor Lab, August 10, 2005
Chris Lima, Memorial Sloan Kettering Cancer Center
Insights into E3 ligase activity and SUMO conjugation
Junjie Hu, NYU School of Medicine
Structural Basis for phosphotyrosine
recognition by the SH2 domains of SH2B and APS
Brajesh K. Rai, Fisher Lab, Albert Einstein
College of Medicine
Multiple Mapping Method: A novel
approach to the sequence-to-structure alignment problem in comparative
protein structure modeling
How does it cut? Insights into the incision reactions during nucleotide excision repair
Ned Seeman, New York University
DNA: Not Merely the Secret of Life
Corey Mandel, Tong Lab, Columbia
University
Trials and tribulations in the
structure determination of CPSF 100
Steve Dierker, National
Synchrotron Light Source, Brookhaven Laboratory
NSLS-II: The Future National
Synchrotron Light Source
Eric Greene, Columbia University
Slip sliding away: visualizing
one-dimensional diffusion of proteins on DNA
Joe Marcotrigiano, Rice Lab,
Rockefeller University
The hepatitis C virus autoprotease is
a dimeric cysteine protease with a composite active site
Allan Simpson, GE Healthcare Sweden
Increasing Throughput in Protein
Purification
Robert Spencer & Brian McKeever, Merck
Research Labs
Exploring Membrane Protein Structure
at Merck
Wayne Hendrickson, Columbia University P&S
Follicle Stimulation Hormone(FSH)
stimulation of its receptor
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Fiftysecond Meeting, April 20, 2005
Benoit Roux, Weill Medical College of Cornell University:
Selectivity of the K+ Channel: The Importance of Protein
Flexibility
Moosa Mohammadi, NYU School of Medicine
Structural Basis for FGF Receptor
Activation: Implications in Development and Disease
John Berriman, New York Structural Biology Center
Molecular Portraits by Cryo-EM: Old
Puzzles in Rotavirus
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Fiftyfirst Meeting. February 23, 2005
Steve Hubbard,New York University:
Structural studies of MuSK receptor tyrosine kinase
Aneel Aggarwal, Mount Sinai School of Medicine:
David Wah, Public Health Research Institute:
A Substrate-Delivery System for an Energy-Dependent Proteolytic
Machine
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Fiftieth Meeting. December 15, 2004
Hermann Schindelin, Stony Brook University:
Gephyrin - A bridge between molybdenum cofactor biosynthesis and
neuroreceptor anchoring
Milton Werner, Rockefeller University:
In search of the mechanism of transcriptional transactivation
Scott Strobel, Yale University:
Crystal structure of a group I intron splicing intermediate
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Fortyninth Meeting. October 6, 2004
Xiang-Peng Kong, Skirball Institute, NYU School of Medicine:
CryoEM studies of bladder epithelial membrane plaques: structural
and functional implications
Hernando Sosa, Albert Einstein College of Medicine:
Configuration of the Kinesin-Microtubule Interaction as Seen by
Fluorescence Polarization Microscopy
Qiu-Xing Jiang, Rockefeller University:
Single particle analysis of a voltage-gated potassium channel KvAP
in an open conformation
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Fortyeighth Meeting. April 7, 2004
Dinshaw Patel, Memorial Sloan-Kettering Cancer Center:
Protein-RNA Recognition Events in RNA Interference
Caroline Kisker, Stony Brook University:
Lesion (in)tolerance reveals insights into DNA replication fidelity
Roberto Sanchez, Mount Sinai School of Medicine:
How good/bad are comparative models of protein structure?
_____________________________________________________________________________
Fortyseventh Meeting. February 4, 2004
Kathy Borden, Mount Sinai School of Medicine:
Accidental Drug Discovery: The antiviral Ribavirin directly inhibits
eIF4E through physical mimicry of the m7Gcap
David Stokes, Skirball Institute, New York University School of
Medicine:
Electron tomography of desmosomes
Bradford Graves, Hoffman - La Roche, Inc.:
If at first you don't succeed ...: The binding of small molecule
antagonists to Mdm2
_____________________________________________________________________________
Fortysixth Meeting. December 3, 2003
Aneel Aggarwal, Mount Sinai School of Medicine:
SAM I am: A new RNA Binding Motif
Ming-Ming Zhou, Mount Sinai School of Medicine:
Probing the Molecular Mechanisms of the RNA-induced Silencing Pathway
Leemor Joshua-Tor, Cold Spring Harbor Laboratory:
The PAZ domain of Argonaute2: siRNAs at RISC
_____________________________________________________________________________
Fortyfifth Meeting. October 1, 2003
Lawrence Shapiro, Columbia University:
Adipocyte-secreted hormones modulate insulin action
Marilyn Gunner, City College:
Ruth Stark, CUNY College of Staten Island:
NMR studies of Molecular Structure and Dynamics in Fatty
Acid-Binding Proteins
_____________________________________________________________________________
Fortyfourth Meeting. May 28, 2003
Mark Chance, Albert Einstein Center for Synchrotron Biosciences:
Visualizing the Ca+2 Dependent Activation of Gelsolin Using
Synchrotron Footprinting
Erec Stebbins, Rockefeller University:
Manipulation of the Host Cytoskeleton by SipA of Salmonella
Clay Bracken, Weill Medical College of Cornell University:
NMR studies of helix formation and the unfolded state
_____________________________________________________________________________
Fortythird Meeting. March 26, 2003
Milton Werner,Rockefeller University:
Rethinking the activation mechanism of tumor necrosis factor death
receptors
John Hunt, Columbia University:
Structural mechanics of the SecA translocation ATPase and the
'A-protein' paradigm
Benoit Roux, Weill Medical College of Cornell University:
Theoretical and Computational Models of Ion Channels
_____________________________________________________________________________
Fortysecond Meeting. February 12, 2003
Chris Lima,Weill Medical College of Cornell University:
Capping mRNA, structural insights into co-transcriptional mRNA
processing
Stephen Burley, Structural Genomix:
Structure-based discovery of human protein kinase inhibitors
Themis Lazaridis, City College of New York:
Modeling membrane proteins in an implicit membrane
_____________________________________________________________________________
Fortyfirst Meeting. November 6, 2002
Eric Gouaux, Columbia University:
Mechanisms for activation and desensitization of glutamate receptors
Andy Neuwald, Cold Spring Harbor Laboratory:
Canonical Ras, Rab, Rho and Ran GTPase structural features and Ran's
Cterminal and basic patch mechanism
Rui-Ming Xu, Cold Spring Harbor Laboratory:
Structural studies of transcription silencing
_____________________________________________________________________________
Fortieth Meeting. May 29, 2002
Fred Hughson, Princeton University:
Structural identification of a bacterial quorum-sensing signal
containing boron
Mark Girvin, Albert Einstein College of Medicine:
Solution NMR of membrane proteins
Carlos Simmerling, SUNY Stonybrook:
Simulation of biomolecular structure and dynamics on large clusters
of personal computers
_____________________________________________________________________________
Thirtyninth Meeting. March 6, 2002
Yigong Shi, Princeton University
Structural mechanism of Apaf-1-mediated apoptosis
Diana Murray, Weil Medical College, Cornell University
Electrostatic regulation of protein-membrane interactions in
subcellular
targeting: Insights from computational analysis
Stephen Burley, Rockefeller University and Structural GenomiX
X-ray structure of the NC2-TBP-DNA ternary complex
_____________________________________________________________________________
Thirtyeighth Meeting. January 10, 2002
An-Suei Yang, Columbia University
Local sequence codes for protein structures
Hermann Schindelin, SUNY Stony Brook
Mechanistic insights into ubiquitin activation from the crystal
structure of
a bacterial MoeB-MoaD complex
Dimitar Nikolov, Sloan-Kettering Institute
Structure of an Eph receptor/ephrin complex
_____________________________________________________________________________
Thirtyseventh Meeting. November 28, 2001
Benoit Roux, Weill Medical College of Cornell University
Michael Becker, Brookhaven National Laboratory
Christopher Lima, Weill Medical College of Cornell University
_____________________________________________________________________________
Thirtysixth Meeting. October 3, 2001
Barry Honig, Columbia University
Ming-Ming Zhou, Mount Sinai School of Medicine
Leemor Joshua-Tor, Cold Spring Harbor Laboratory
_____________________________________________________________________________
Thirtyfifth Meeting. May 30, 2001
Nick Tonks, Cold Spring Harbor Laboratory
From Structure to Function of Protein Tyrosine Phosphatases
Marilyn Gunner, City University of New York
Motifs for Stabilizing Charges in Proteins
Seth Darst, The Rockefeller University
Structural Studies of Prokaryotic Transcription
_____________________________________________________________________________
Thirtyfourth Meeting. March 7, 2001
Min Lu, Weill Medical College of Cornell University
HIV-1 Membrane Fusion and its Inhibition
Kathy Borden, Mount Sinai School of Medicine
Structure, Function of PHD fingers: Does this have a familiar RING?
Hao Wu, Weill Medical College of Cornell University
Structural Studies of Caspase Inhibition
_____________________________________________________________________________
Thirtythird Meeting. January 8, 2001
Dimitar Nikolov, Sloan Kettering Institute
Structural Studies of a Nucleotidylyltransferase as a Tool for in
vitro Combinatorial Biosynthesis of Libraries
Joachim Frank, The Wadsworth Center
The Ribosome in Motion - Conformational Changes Observed by
Three-Dimensional Cryo-EM
Stephen Burley, The Rockefeller University
Structural Genomics of Cholesterol Biosynthesis
_____________________________________________________________________________
Thirtysecond Meeting. November 29, 2000
Steven Smith, SUNY Stony Brook
Internal Packing of Helical Membrane Proteins
Burkhard Rost, Columbia University
John Kuriyan, Rockefeller University
Structural Analysis of DNA Polymerase Clamp Loading
_____________________________________________________________________________
Thirtyfirst Meeting. September 27, 2000
Barry Honig, Columbia University
Combining bioinformatics and biophysics to predict protein structure
and function
Daniel Wyss, Schering Plough Research Institute
Structure and dynamics of the hepatitis C virus protease and helicase
Liang Tong, Columbia University
Structural basis of signal transduction by toll/IL1-R domains
_____________________________________________________________________________
Thirtieth Meeting. May 17, 2000
MICHAEL ROSEN, Sloan-Kettering Cancer Institute
Regulation of the Wiskott-Aldrich Syndrome Protein
STEVAN HUBBARD, NYU Medical Center
Structural Basis of Fibroblast Growth Factor Receptor Activation
TAMAR SCHLICK, NYU
Molecular Dynamics Analysis of DNA TATA-box variants
_____________________________________________________________________________
Twentyninth Meeting. March 22, 2000
ANN McDERMOTT, Columbia University
NMR studies of biomolecules
LARRY SHAPIRO, Mount Sinai
Structure and function of the obesity-related protein, tubby
CHRIS LIMA, Weill Medical College of Cornell University
Proteolytic regulation in the SUMO/Smt3 pathway
_____________________________________________________________________________
Twentyeighth Meeting. January 19, 2000
MARK GIRVIN, Albert Einstein College of Medicine
How Proton Translocation Drives Rotation in the ATP Synthase
ANNA MARIE PYLE, Columbia University
A kinetic and structural framework for helicase activity in the
DexH/D proteins
STEWART SHUMAN, Sloan-Kettering Institute
Structure and mechanism of the mRNA capping apparatus
_____________________________________________________________________________
Twentyseventh Meeting. December 1, 1999
Seth Darst, Rockefeller University:
Title to be arranged
Caroline Kisker, SUNY, Stony Brook
Crystal structure of UvrB provides insight into the mechanism of
nucleotide excision repair
David Beveridge, Wesleyan University
Title to be arranged
_____________________________________________________________________________
Twentysixth Meeting. September 29, 1999
Terry Gaasterland, Rockefeller University:
Comparative Genomics
Ming-Ming Zhou, Mount Sinai School of Medicine:
Protein-Protein Interactions in Chromatin Remodeling
Dinshaw Patel, Sloan-Kettering Institute:
Adaptive Recognition by Nucleic Acid Aptamers
_____________________________________________________________________________
Twentyfifth Meeting. May 19, 1999
Mike Rosen (Sloan-Kettering Institute)
Aneel Aggarwal (Mt. Sinai School of Medicine)
Gaetano Montelione (Rutgers University)
_____________________________________________________________________________
Twentyfourth Meeting. March 24, 1999
Andrej Sali (Rockefeller University)
Hao Wu (Cornell University Medical College)
Ned Seeman (New York University)
_____________________________________________________________________________
Twentythird Meeting. January 20, 1999
Eric Gouaux (Columbia University)
Burkhard Rost (Columbia University)
Milton Werner (Rockefeller University)
_____________________________________________________________________________
Twentysecond Meeting. November 11, 1998
Rich Friesner (Columbia University)
Axel Brünger (Yale University)
Thierry Fischmann (Schering-Plough Research Institute)
_____________________________________________________________________________
Twentyfirst Meeting. September 9, 1998
Rod Mackinnon, Rockefeller University
Art Palmer, Columbia University
Maria-Luisa Tasayco, City College
_____________________________________________________________________________
Twentieth Meeting. May 27, 1998.
Tamar Schlick, NYU
Elena Conti, Rockefeller University (Kuriyan Lab)
Steve Almo , Albert Einstein College of Medicine
_____________________________________________________________________________
Nineteenth Meeting. March 25, 1998.
Yale Evening:
Mark Gerstein
Andrew Miranker
Paul Sigler
_____________________________________________________________________________
Eighteenth Meeting. January 7, 1998.
David Stokes, NYU Medical Center
Tom Sakmar, Rockefeller
Wayne Hendrickson, Columbia University
_____________________________________________________________________________
Seventeenth Meeting. November 5, 1997.
Stevan Hubbard, NYU Medical Center
Dinshaw Patel, Sloan-Kettering Institute
Ann McDermott, Columbia University
_____________________________________________________________________________
Sixteenth Meeting. September 24, 1997.
Stephen Burley, Rockefeller University
Barry Honig, Columbia University
Dixie Goss, Hunter College
_____________________________________________________________________________
Seventh Meeting. November 29, 1995.
Stephen Burley, Rockefeller University
Marilyn Gunner, City College, CUNY
Art Palmer, Columbia University
_____________________________________________________________________________
Sixth Meeting. September 27, 1995.
Nikola Pavletich, Sloan-Kettering Institute
Bob Callender, City College, CUNY
Barry Honig, Columbia University
_____________________________________________________________________________
Fifth Meeting. May 17, 1995.
Paula Fitzgerald, Merck Research Labs
?
Harel Weinstein, Mt. Sinai School of Medicine
_____________________________________________________________________________
Fourth Meeting. March 8, 1995.
Ann McDermott, Columbia University
Andrej Sali, Rockefeller University
Stephen Burley, Rockefeller University
_____________________________________________________________________________
Third Meeting. January 11, 1995.
Ruben Abagyan, NYU Medical Center
Wayne Hendrickson, Columbia University
Dinshaw Patel, Sloan-Kettering Institute
_____________________________________________________________________________
Second Meeting. November 15, 1994.
Rich Friesner, Columbia University
Ned Seeman, New York University
Giovanna Scapin, Albert Einstein College of Medicine
_____________________________________________________________________________
First Meeting. September 28, 1994.
Anthony Nicholls, Columbia University
Nikola Pavletich, Sloan-Kettering Institute
Brian Chait, Rockefeller University