List of participating research groups

Summer Meeting 2013, Mount Sinai School of Medicine (#69)

Helen Berman, Rutgers Univ. Structural Biology Data and Information Resources: New Features and Functionalities

Olga Boudker, Weill Cornell Med. Coll. The structural plasticity and dynamics of a glutamate transporter homologue

Qing R. Fan, Columbia University Mechanisms of heterodimerization, ligand recognition, and activation in human GABA(B) receptor

Pu Gao, Sloan Kettering Institute(Patel Group) Structure-function Studies of Cytoplasmic Sensors of dsDNA in Metazoans that Activate the STING Pathway

Morten Jensen, Shaw Research Voltage-gated potassium channels: Permeation, gating, and modulation

Xin-Yun Huang, Weill Cornell Med. Coll. Crystal structure of oligomeric β1-adrenergic G protein-coupled receptors

Nathaniel Traaseth, New York University Induced Conformational Changes of the Multidrug Resistance Transporter EmrE Probed by Solid-State NMR Spectroscopy

Eli Rothenberg, New York University Sch. Med. A Single-Molecule View of DNA Double Stranded Break Repair

Stuart Shuman, Sloan Kettering Inst. Structure and mechanism of a eukaryal tRNA restriction enzyme

Hernando Sosa, Albert Einstein College of Medicine Structural insights into the mechanism of microtubule depolymerization by kinesin-13s

Dazhi Tan, Columbia (Tong Lab) Crystal structure of the histone mRNA stem-loop, human stem-loop binding protein and 3′hExo ternary complex

Elizabeth Wasmuth, Sloan Kettering Inst. (Lima Lab) Structural and functional characterization of eukaryotic RNA exosomes

Albert Weixlbaumer, Rockefeller Univ. (Darst Lab) Structural basis of transcriptional pausing in bacteria

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Original pictures from Samuel Sparks

The conveners thanks the Mount Sinai School of Medicine and Iban Ubarretxena for the outstanding real estate. The New York Structural Biology Center, the New York Academy of Sciences, and Cold Spring Harbor Laboratory provided infrastructural support.

    2013 Winter Meeting, New York Academy of Science (#68)

    Aneel Aggarwal, Mount Sinai School of Medicine
    "DNA - Protein Recognition : Engineering New Specificity"
    Karim-Jean Armache, NYU Med
    "Structural characterization of silent chromatin"
    Grégory Boël, Columbia University (Hunt Lab)
    "Structural biology powering discovery biology: elucidation of the physiological function and molecular mechanism of a novel family of translation factors that regulate commitment of energetic resources to protein synthesis"
    Elizabeth Campbell, Rockefeller University (Darst Lab)
    "Structure and function of Car D, an essential Mycobacterial transcription factor"
    Andras Fiser, Albert Einstein College of Medicine
    "Modeling proteins using a super-secondary structure library and NMR chemical shift information"
    Charalampos (Babis) Kalodimos, Rutgers
    "Recognition of unfolded proteins by molecular chaperones"
    Steve Long, Memorial Sloan Kettering Cancer Center
    "Crystal structure of the calcium release-activated calcium channel Orai"
    Filippo Mancia, Columbia University
    "Crystal structure of sulfate transporter CysZ"
    Ivo Melčák, Rockefeller University (Blobel Lab)
    "Architecture of the Transport Channel of the Nuclear Pore Complex"
    Greg Petsko, Weill Cornell
    "The Structural Biology of Parkinson's Disease"
    Alexandros Pertsinidis, Memorial Sloan Kettering Cancer Center
    "Sub-diffraction fluorescence imaging of molecular structures and interactions"
    Deniz Temel, City College of New York (Ghose Lab) 1
    "Regulatory Interactions between a Bacterial Tyrosine Kinase and its Cognate Phosphatase"



    Outstanding Poster Awards

    • Moshe Dessau, Yale University, "Crystal structure of glycoprotein C from Rift Valley Fever virus"

    • Cheng-Tsung Lai, Stony Brook University, "Structural mechanism for the slow-onset inhibition of mycobacterium tuberculosis inha "

    • Weifeng Liu, Albert Einstein College of Medicine, "Exploration and blockade of decoy strategy: crystal structure of the light:Dcr3 complex and rational design of Dcr3 antagonists"


    Prizes supported by the Suraj P. Manrao Science Foundation, and Nature Structural and Molecular Biology

    Pictures from Winter Meeting 2013


    2012 Summer Meeting, Weill Cornell Medical College (#67)

    Prof. Steven Almo, Albert Einstein College of Medicine of Yeshiva University
    "From PDBs to Pathways"

    Prof. David Fushman, Dept. of Chemistry and Biochemistry, U. Maryland
    'Deciphering the "ubiquitin" code.'

    Prof. David Jeruzalmi, Dept. of Chemistry, CCNY and Molecular and Cellular Biology, Harvard University
    "Inner workings of the UvrA-UvrB DNA damage sensor"

    Prof. Wayne Hendrickson, Columbia University
    "Multi-crystal native SAD structures routinely from light-atom anomalous diffraction"

    Dr. Nathan Karpowich, NYU (Wang lab)
    "Structure and Assembly of an ECF Transporter for Riboflavin"

    Prof. Themis Lazaridis, CCNY, CUNY
    "Modeling protein-membrane interactions"

    Dr. David LeMaster, Wadsworth Center, Albany
    "Rotational Velocity Rescaling of Molecular Dynamics Trajectories for Direct Prediction of Protein NMR Relaxation"

    Prof. Michael Rout, Rockefeller University
    "The Hole Picture? Architecture and Mechanism of the Nuclear Pore Complex"

    Dr. Yibing Shan, D.E. Shaw Research,
    "Models of full-length EGF receptors and the effects of the oncogenic cancer mutations"

    Kate Stafford, Columbia U (Palmer lab)
    "Exploring the conformational dynamics of ribonuclease H by integration of molecular dynamics simulations and NMR spectroscopy"

    Prof. Iban Ubarretxena-Belandia, Mount Sinai School of Medicine
    "Electron microscopy structure of Leucine Rich Repeat Kinase 2 involved in Parkinson disease"

    Prof. Hao Wu, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
    "Oligomeric signalosomes in TLR and TNFR pathways - a new concept in signaling?"

    Illustration 1: Presenters – Michael Rout, Steven Almo, Yibing Shan, Iban Ubarretxena-Belandia, David Jeruzalmi, Nathan Karpowich ;

    (below) Hao Wu, David Fushman, Kate Stafford, Themis Lazaradis, David LeMaster, & Wayne Hendrickson

    Illustration 2: Poster Awardees, presented by Suraj Manrao. Romina Mancusso (with G. Glenn Gergorio, Qun Liu, and Da-Nang Wang -- NYU Med) "Structure and Mechanism of a bacterial sodium-dependent dicarboxlate transporter" : Yu Zhang (Rutgers) "Structural basis of transcription initiation" : Yogesh Gupta (with Aneel Aggarwal, MSSM) "Structural insights into the assembly and shape of type III restriction - modification EcoP151 complex by SAXS"

    2012 Winter Meeting, New York Academy of Science (#66)

    Speakers & Chairs from 2012 Summer Meeting at New York Academy of Science (L->R) Wolfgang Peti, Anthony Armstrong, Robert Sweet, Burce Ergel, Liang Tong, Tali Lavy, David Stokes, Ken Dill, David Eliezer, Ming Zhou, David Cowburn (not shown, Tarun Kapoor, Helen Berman, Hiro Furikawa, Chris Sander)

    Poster awardees (and one of their prizes!) : Sozanne R. Solmaz (Rockefeller U.), Paul Robustelli (Columbia U.), Breann C. Brown (Brown U.). Poster awards from Nature Structural and Molecular Biology.

    2011 Summer Meeting, Cold Spring Harbor Laboratory, 2011 (#65)

    Scott Blanchard, Weill Cornell Medical College; Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding

    Paul Driscoll, University College London; Tracking death domain complex assembly with NMR

    Qing Fan, Columbia University; Structural studies of human GABA(B) receptor

    Evripidis Gavathiotis, Albert Einstein College of Medicine; Tracing a Killer's Path: Structural insights into the Activation Pathway of Pro-Apoptotic BAX
    Wayne Hendrickson, Columbia University; Structural Analysis of SLAC1-family Anion Channel Activity

    Gaetano Montelione, Rutgers University; Structural Biology of the Human Cancer Protein Interaction Network

    Vivek Patel, Albert Einstein College of Medicine (Singer lab); Conserved RNA recognition element identifies ZBP1-operated post-transcriptional regulatory networks

    Thomas Schalch, Cold Spring Harbor Lab (Joshua-Tor lab); Coupling RNAi to Heterochromatin: Insights into the Structure of the RITS Complex

    Alexander Shekhtman, SUNY at Albany; Signal transduction in RAGE: structural biology of the receptor for advanced glycation end products

    Jikui Song, Sloan-Kettering Institute (Patel lab); DNMT1 and maintenance DNA methylation

    Yinghao Wu, Columbia University (Honig lab); Multiscale simulation of cadherin-mediated cell adhesion

    Sponsored Lunchtime presentation -- Brian Lang, GE; Using SPR to study interactions of membrane proteins

    Speakers & Chairs from 2011 Summer Meeting at Cold Spring Harbor Laboratory
    (L->R) David Cowburn, Thomas Schalch, Yinghao Wu, Evripidis Gavathiotis, Alexander Shekhtman, Qing Fan, Gaetano Monterione, Colin Driscoll, Ruth Stark, Wayne Hendrickson, Vivek Patel, Hao Wu, Jikui Song. Missing, Scott Blanchard.

    Poster awardees (and their prizes!) :
    Guozhou Xu, Weill Cornell Medical College, Structure, Substrate Specificity and Mechanism of Kinase Activation of the IkB Kinase β (IKKβ);
    Kotaro Nakanishi, MSKCC;Structural basis for double-stranded RNA processing and insights into the catalytic mechanism and evolution of a non-canonical Dicer.
    Qiangfeng Cliff Zhang, Columbia Univ. Towards the integration of structural and systems biology: structure-based studies of protein-protein interactions on a genome-wide scale

    Special award of NSMB subscription: Jennifer Hackett (Dalton School), Steven Mason (NSMB)

    2011 Winter Meeting, New York Academy of Sciences, January 19, 2011

    Eric Greene, Columbia University
    High-throughput Single Molecule Imaging of Protein-DNA Interactions

    Rinku Jain (Aggarwal Lab) Mount Sinai School of Medicine
    SAXS Analysis of DNA Polymerase Delta

    Wei-Li Liu, Einstein College of Medicine
    Nanoscale Probing of the Tumor Suppression Transcription Initiation Machinery

    Ming-Ming Zhou, Mount Sinai School of Medicine
    Learning the Chromatin Language of Gene Expression

    Joel Butterwick (MacKinnon Lab), Rockefeller University
    Solution Structure and Phospholipid Interactions of the Isolated Voltage Sensor Domain from KvAP

    Steven Ealick, Cornell University
    ThiC and Dph2: Two Unpredicted Radical SAM Enzymes

    John Hunt, Columbia University
    A Rational Approach to Engineering Improved Protein Crystallization

    Michael Ward, New York University
    Crystal Growth Inhibitors for the Prevention of L-Cystine Kidney Stones through Molecular Design

    David Case, Rutgers University
    Testing Biomolecular Force Fields against Crystal and NMR Data

    Andisheh Abedini (Schmidt Lab), New York University School of Medicine
    Toxic Intermediates during IAPP Amyloid Formation

    David E. Shaw, D.E. Shaw Research
    Millisecond-Long Molecular Dynamics Simulations of Proteins on a Special-Purpose Machine

    Award Winning Posters

    Noel Carrascal, Stony Brook University
    Prediction of side-chain conformations at the protein-DNA interface

    Jaehyun Cho, Columbia University
    Tuning Protein Autoinhibition by Domain Destabilization

    Tanvir Shaikh, Wadsworth Center
    Association of Ribosomal Subunits As Studied By Time-Resolved Cryo-Electron Microscopy

    Poster Award Winners (left to right): Noel Carrascal, Jaehyun Cho, Tanvir Shaikh

    Speakers & Chairs from 2011 Winter Meeting at the New York Academy of Sciences
    left to right: David Stokes, David Cowburn, Rinku Jain, Wei-Li Liu, David Case, Eric Greene, Joel Butterwick,
    Steven Ealick, Andisheh Abedini, David Eliezer, Ming-Ming Zhou, Michael Ward, John Hunt, David Shaw, Hao Wu

    2010 Summer Meeting, Cold Spring Harbor Laboratory, August 4, 2010

    Nicolas Nassar, Stony Brook University
    Structural, functional & mechanistic insights into the Sts family of phophatases

    Pravin Nair (Shuman Lab), Sloan Kettering Cancer Center
    LigD 3’-phosphoesterase structure unveils a new superfamily for DNA repair

    John Blanchard, Einstein College of Medicine
    Targets in tuberculosis

    Yossi Schlessinger, Yale University

    Guozhou Chen (Hughson lab), Princeton University
    Disrupting quorum sensing: mechanism underlying antagonist function

    Hao Wu, Weill Cornell Medical College
    Elegant mechanisms of death domain assembly in apoptosis and immunity

    Bob Sweet, Brookhaven National Lab
    Essence of NSLSII for structural biologists

    Jonathan Javitch, Columbia University
    Single-molecule dynamics of gating in a neurotransmitter transporter

    Jae-Hyun Cho (Palmer Lab), Columbia University
    Tuning Protein Autoinhibition by Domain Destabilzation

    Ann McDermott, Columbia University
    Enzyme Motions: Studies by Solid State NMR

    Ming Zhou, Columbia University
    Crystal Structure of Bacterial Potassium Ion Transporter TrkH

    Kehui Xiang (Tong Lab), Columbia University
    Structure of symplekin-Ssu-72-CTD phosphopeptide complex and implications for pre-mRNA polyadenylation

    Chris Lima, Sloan Kettering Cancer Center
    Structure and function in the SUMO pathway

    Selected Speakers & Chairs from 2010 Summer Meeting at Cold Spring Harbor Laboratory

    2010 Winter Meeting, New York Academy of Sciences, January 13, 2010

    Alessio Accardi, Weill Cornell Medical College
    Molecular basis of ion binding & selectivity in CLC transporters and channels

    Mark Ptashne, Sloan Kettering Cancer Institute
    Effect of RSC/nucleosome complex on chromatin architecture and expression of the GAL genes of yeast

    Wayne Hendrickson, Columbia University
    Signal transmission through the TMAO-responsive histidine kinase

    Vern Schramm, Einstein College of Medicine
    Enzymatic transition states in drug design

    Sebastian Doniach
    What can SAXS tell us about conformational changes in small functional RNAs

    Ted Scovell, NYC SMART Team
    Get SMART: Using physical models to teach protein structure

    Moosa Mohammadi, NYU School of Medicine
    Molecular basis for FGF receptor autoinhibition

    Xin-Yun Huang, Weill Cornell Medical College
    Structural basis for migrastatin analogues targeting fascin to inhibit tumor metastasis

    Da-Neng Wang, NYU School of Medicine
    Structure and mechanism of a pentameric formate channel from Vibrio cholerae

    Axel Innis (Steitz Lab), Yale University
    Regulatory nascent peptides and the ribosome

    Seth Darst, Rockefeller University
    Structural basis for Pribnow box recognition by the bacterial RNA polymerase sigma subunit

    Award Winning Posters

    Peng Liu, Columbia University
    Prediction of side-chain conformations at the protein-DNA interface

    Nicolas Reyes, Weill Cornell Medical College
    Transport mechanism of a prokaryotic homology of glutamate transporters

    Deborah Stoner-Ma, Brookhaven National Lab
    Correlated single crystal spectroscopy and macromolecular X-ray crystallography at beamline X26-C of the NSLS

    Lee Tremblay, Einstein College of Medicine
    The structure-based design of novel inhibitors of Mycobacterium tuberculosis b-lactamase as chemotherapeutic agents

    Sean West, Columbia University
    Minor groove electrostatics provides a molecular origin for protein-DNA specificity

    Poster Award Winners (left to right): presented by Boyana Konforti (Nature Struct & Molec Biol), Sean West (Columbia)
    Peng Liu (Columbia), Nicolas Reyes (Cornell), Deborah Stoner-Ma (Brookhaven), Lee Tremblay (Einstein),


    2009 Summer Meeting, Cold Spring Harbor Laboratory, August 5, 2009

    Olga Boudker, Weill Cornell Medical College
    Alternating access mechanism of glutamate transporters

    Elena Levin (Ming Zhou Lab), Columbia University
    The 2.3 A crystal structure of a bacterial urea transporter

    Liguo Wang (Fred Sigworth Lab), Yale University
    Cryo-EM structure of the BK channel in a lipid membrane

    Steve Smith, Stony Brook University
    Multiple switches in the activation of the visual receptor rhodoopsin

    Brian Loomis (Stephen Goff Lab), Columbia University
    The Moloney Murine Leukemia Virus Pseudoknot: A pH-Dependent Riboswitch

    Zimei Bu, Fox Chase Cancer Center
    A conformational switch autoregulates the scaffolding protein NHERF1

    Rebecca Page, Brown University
    Using Structural Biology to Combat Antibiotic Resistance

    Jae Hyun Bae (Joseph Schlessinger Lab), Yale University
    Tyrosine kinase selectivity controlled by secondary SH2 binding site

    Yi Ren (Fred Hughson Lab), Princeton University
    Molecular Architecture of the Dsl1 Vesicle Tethering Complex

    Elias Lolis, Yale University
    Macrophage migration inhibitory factor from Ancylostoma ceylanicum

    Jianping Zheng (Nadrian Seeman Lab), New York University
    Design and Self-Assembly of 3D DNA Crystals

    Remo Rohs (Barry Honig Lab), Columbia University
    Role of DNA Shape in Protein-DNA Recognition

    David Wah, Public Health Research Institute
    C-terminal Domain of Transcription Factor IIB from Trypanosoma brucei

    Selected Speakers & Chairs from 2009 Summer Meeting at Cold Spring Harbor Laboratory
    Front row: Yi Ren, Ruth Stark, Jianing Zheng, Rebecca Page, Brian Loomis, Elena Levin
    Second row: David Stokes, David Eliezer, Jae Hyun Bae, David Wah, Steve Smith, Hao Wu
    Third row: Liguo Wang, Olga Boudker, Remo Rohs


    2009 Winter Meeting, New York Academy of Sciences, January 22, 2009

    David Green, Stony Brook University
    The structural glycobiology of HIV: Insights from computational models

    Davide Provasi (Marta Filizola Lab), Mt. Sinai
    Stimulating long timescale biological processes with metadynamics

    Paramjit Arora, New York University
    Synthetic approaches for targeting protein interfaces

    Rajesh Kumar Prakash (Leemor Joshua-Tor Lab), Cold Springs Habor
    Turning ON transcription: A sugary tale revisited

    Ewa Folta-Stogniew, Yale University
    Light scattering for analysis of oligomerization and protein interactions

    Steve Hubbard, New York University
    Structural basis for protein recruitment to the insulin receptor and muscle specific kinase

    Vinzenz Unger, Yale University
    Insights into the mechanisms of copper transport

    David Borhani, DE Shaw Institute
    Block or lock

    Jin Kim Montclare, New York University
    A. oryzae cutinase: Biocatalyst for synthetic ester and polyester degradation

    David Gadsby, Rockefeller
    The ion pathway through the Na,K-ATPase pump

    Daniel Schmidt (MacKinnon Lab), Rockefeller
    Turning Kv channel by the mechanical state of the lipid membrane

    Crina Nimigean, Weill Cornell Medical
    A novel mechanism of K channel selectivity revealed b ionic interactions within the pore

    Selected Speakers & Chairs from 2009 Winter Meeting at the New York Academy of Sciences
    David Gadsby, Crina Nimigean, David Eliezer, Hao Wu, Paramjit Arora, Ruth Stark, David Provasi
    Jin Kim Montclare, David Green, Ewa Folta-Stogniew, Steve Hubbard, Rajesh Kumar Prakash, David Stokes, Vinzenz Unger


    2008 Summer Meeting, Cold Spring Harbor Laboratory August 6, 2008

    Dax Fu, Biology, Brookhaven National Lab
    Structure and mechanism of the zinc transporter YiiP

    Chunyan Tang (Li Lab), Biology, Brookhaven National Lab
    Fiber formation in bacteria by the Chaperone/Usher pathway

    Robert Abel (Friesner Lab), Chemistry, Columbia University
    The role of the solvent in protein-ligand binding and protein structure

    Neer Asherie, Physics & Biology, Yeshiva University
    Precipitant chirality and the crystallization of thaumatin

    Agni Ghosh (Lima Lab), Structural Biology, Sloan Kettering Inst
    Fcp1, the phosphatase required for RNAPII turnover

    Dinshaw Patel, Structural Biology, Sloan Kettering Inst
    Structure of Argonaute with bound guide strand and message

    Marc Allaire, Beamline, Brookhaven National Lab
    Discussion of X-ray data collection: stationary crystals - integrated spots

    Wolfgang Peti, Mol Pharm, Physiol & Biotech, Brown
    Structural basis for protein phosphatase 1 regulation

    Richard Pomerantz (O'Donnell Lab), DNA Replication, Rockefeller
    Mechanism of replisome bypass of a co-directional RNA polymerase

    Eva Vanamee (Aggrawal Lab), Structural & Chemical Biol, Mt Sinai
    DNA cutting molecular scissors: from bench to bedside

    Allen Orville, Biology, Brookhaven National Lab
    A fl avin-C4a-oxygen intermediate

    Qian Yin (Wu Lab), Biochem & Struct Biol, Cornell Med College
    Structural Basis of TRAF6-mediated Ubiquitination

    Dario Ghersi (Sanchez Lab), Structural & Chemical Biol, Mt Sinai
    Computational approaches to detect and exploit protein binding sites

    Joachim Frank, Biochem & Mol Biophys, Columbia
    The Ribosome: a molecular machine with intrinsic instability

    Selected Speakers & Chairs from 2008 Summer Meeting at Cold Spring Harbor Laboratory
    front: Hao Wu, Allen Orville, Agni Gosh, Chungyan Tang, Eva Vanamee, David Eliezer, Dario Ghersi
    rear: Richard Pomeranz, David Stokes, Wolfgang Peti, Joachim Frank, Marc Allaire, Neer Asherie, David Cowburn, Robert Abel


    2008 Winter Meeting, Weil Cornell Medical College February 29, 2008

    Yarden Opatowsky (Schlessinger Lab), Pharmacology, Yale Univ
    Activation of receptor tyrosine kinase Kit by Stem Cell Factor

    Carlos Escalante (Aggarwal Lab), Struct & Chem Biol, Mt. Sinai
    Structural and functional studies of AAV Rep proteins

    Matt Bick (Darst Lab), Molec Biophysics, Rockefeller University
    How to switch off a histidine kinase: 2√… structure of KinB/Sda

    Liang Tong, Columbia University
    Structural Studies of Fatty Acid Metabolism and the Obesity Epidemic

    Linda Nicholson, Physical Biochemistry, Cornell Univ
    Pin1, a molecular timer in Alzheimer’s disease

    Alex Shekhtman, Chemistry, SUNY Albany
    In-vivo Biochemistry using NMR Spectroscopy

    Charalampos Kalodimos, Chemistry, Rutgers Univ
    Structural basis for assembly of large protein machineries by NMR

    Da-Neng Wang, Struct Biol, NYU School of Medicine
    LeuT-desipramine structure reveals how antidepressants work

    Qinglian Liu (Hendrickson Lab), Biochem & Biophys, Columbia
    Insights into Hsp70 chaperone from a structure of yeast Hsp110 Ssel

    Holger Sondermann, Molecular Medicine, Cornell U
    Regulation of the diguanylate cyclase response regulator WspR

    James Love, NYCOMPS, NYSBC
    High throuput membrane protein production at NYCOMPS

    David Stokes, Struct Biol, NYU School of Medicine
    Structure of an ATP-dependent copper pump by cryoEM

    Michael Rout (Cellular and Struc Biol, Rockefeller Univ)
    Structure, function and evolution of the nuclear pore complex


    2007 Summer Meeting, New York Academy of Sciences August 8, 2007

    Erec Stebbins, Structural Microbiology, Rockefeller University
    Structural Microbiology in Bacterial Pathogenesis

    Jung-Hyun Min (Pavletich Lab), Structural Biology, Memorial Sloan Kettering Cancer Center
    DNA-damage Recognition by Rad4 Nucleotide Excision Repair Protein

    Hiro Furukawa, Cold Spring Har/<
    Structure and Function of NMDA receptors

    Iban Ubarretxena, Struct & Chem Biol, Mt. Sinai School of Medicine
    Structural and Functional Studies of Intramembrane Proteases

    Chunyu Wang, Biology, Rensselaer Polytechnic Institute
    Aβ40 Protects Nontoxic Aβ42 Monomer from Aggregation

    Fabien Ferrage, CNRS & NYSBC
    The Nuclear Overhauser Effect for Protein Structure and Dynamics

    Boris Reva (Sander Lab), Computational Biology, Memorial Sloan Kettering Cancer Center
    Assessing the Functional Consequences of Protein Mutations in Cancer

    Tonya Silkov, Pharmacology, Columbia University
    Structural Analysis of ANTH-ENTH-VHS Superfamily

    Richard Bonneau, Biology, New York University
    The Human Proteome Folding Project: Can Rosetta de novo Contribute to Genome Annotation?

    Gino Cingolani, SUNY Upstate Medical University
    Architecture of Viral Cell Envelope Penetration Device

    Greg Boel (Hunt Lab), Biological Sciences, Columbia University
    From Transmembrane Transport to Translational Regulation

    Steve Soisson, Merck
    Structural Basis for Inhibition of Fatty Acid Synthesis by Platensimycin

    Wayne Hendrickson, Biochemistry & Biophysics, Columbia University
    Structure-based Design of HIV Entry Inhibitors

    Selected Speakers & Chairs from 2007 Summer Meeting at the New York Academy of Sciences
    front: Richard Bonneau, Jung-Hyun Min, Chunyu Wang, Hao Wu, Fabien Ferrage
    rear: Hiro Furukawa, Greg Boel, Steve Soisson, Charles Darwin, David Stokes, Wayne Hendrickson, David Eliezer


    2007 Winter Meeting, City College of New York, January 24, 2007

    Tom Muir, Protein Chemistry, Rockefeller University
    The Ins and Outs of K+ channels explored through synthesis

    Jaclyn Greimann (Lima Lab), Structural Biology, Sloan Kettering Inst
    The eukaryotic RNA exosome

    Suvobrata Chakravarty (Zhou Lab), Mol. Physiol. & Biophys., Mt Sinai School of Medicine
    Histone binding selectivity of bromodomains

    Yingkai Zhang, Chemistry, New York University
    Computer simulation of histone modifying enzymes

    Juha Himanen (Nikolov Lab), Structural Biology, Sloan Kettering Institute
    Eph receptor signaling

    Alexei Soares, NSLS, Brookhaven National Laboratory
    Automation program for macromolecular crystallography at NSLS

    Ronald Koder, Physics, City College of New York
    Oxygen binding & activation in a de novo designed hemoprotein

    Erik Martinez-Hackert (Hendrickson's Lab), Biochemistry & Biophysics, Columbia
    Recognition, folding & biogenesis by the chaperone trigger factor

    Steve Almo, Physiology & Biophysics, Einstein College of Medicine
    Stuctural biology of T-cell co-stimulation

    Marc Allaire, NSLS, Brookhaven National Lab
    Transient intermediates in the molecular machinery for nutrient uptake

    Elena Yakubovskaya (Bogenhagen Lab), Pharmacology, SUNY Stony Brook
    EM structure of human mitochondrial DNA poymerase

    Larry Shapiro, Biochem. & Molec. Biophysics, Columbia
    Cellular energy regulation by the AMP-activated protein kinase

    Selected Speakers from 2007 Winter Meeting at CCNY
    front: Steve Almo, Elena Yakubovskaya, Juha Himanen, Jaclyn Greimann
    rear: Suvobrata Chakravarty, Alexei Soares, Marc Allaire


    2006 Summer Meeting, Cold Spring Harbor Laboratory, July 19, 2006

    Ranajeet Ghose, Chemistry, City College of New York
    A molecular anchor for intramembrane proteolysis

    Ying Huang (Xu Lab), Skirball Inst, NYU School of Medicine
    Structural mechanisms of histone code recognition

    Jayakrishnan Nandakumar (Lima Lab), Structural Biology, Sloan Kettering
    Structures of RNA ligase intermediates elucidate the catalytic mechanism

    Scott Blanchard, Physiol & Biophys, Weill Medical College
    Imaging protein synthesis using single-molecule FRET

    Filippo Mancia, Bioch & Mol Biophys, Columbia Univ
    Asymmetry in dimeric associations of the serotonin 2c receptor

    Andrew Stewart (Jacobsen Lab), Physics, Stony Brook University
    Diffraction microscopy: will it lead to crystallography without crystals?

    Julio Fernandez, Biology, Columbia Univ
    Force-dependent activity of thioredoxin at the level of single disulfides

    Ann McDermott, Chemistry, Columbia Univ
    Solid state NMR studies of membrane associated proteins

    Matt Vetting (Blanchard Lab), Biochem, Einstein College of Medicine
    The pentapeptide repeat protein fold and fluoroquinolone resistance

    Giovanna Scapin, Medicinal Chemistry, Merck
    1st & 2nd generation DP-4 inhibitors for treatment of type 2 diabetes

    Carlos Simmerling, Chemistry, Stony Brook University
    Conformational dynamics of HIV-1 protease

    Eric Enemark (Joshua-Tor lab), Struct Biology, Cold Spring Harbor Lab
    DNA translocation by a replicative hexameric helicase

    Dinshaw Patel, Structural Biology, Sloan Kettering Cancer Center
    Structural biology of riboswitches and the histone code

    Selected Speakers & Chairs from 2006 Summer Meeting at Cold Spring Harbor Laboratory
    front: Hao Wu, Dinshaw Patel, Ying Huang, Leemor Joshua-Tor, Ronnie Ghose, Carlos Simmerling,
    Giovanna Scapin, Julio Fernandez, Matt Vetting, David Stokes
    rear: Wayne Hendrickson, Eric Enemark, Filippo Mancia, Anne McDermott, Jayakrishnan Nandakumar
    seated: Andrew Stewart


    2006 Winter Meeting, Hunter College School for Health Sciences, January 24, 2006

    Art Palmer, Biochem & Mol Biophys, Columbia Univ
    Folding of the villin headpiece domain

    Olga Boudker, Physiol & Biophys, Weill Med College
    Structural insights into the mechanism of glutamate transporters

    Alex Kentsis (Osman Lab), Physiol & Biophys, Mt. Sinai
    Protein stability calculations using Monte Carlo and graph manifold learning

    Huilin Li, Biology, Brookhaven National Laboratory
    A tale of two protease complexes

    Diana Murray, Microbiol & Immun, Weill Med College
    PTEN and membrane re-organization: A computational perspective

    Yang Shen (Tong Lab), Biology, Columbia University
    Novel mechanism for inhibition of acetyl-CoA carboxylase by soraphen A

    Rod MacKinnon, Neurobiol & Biophys, Rockefeller
    Voltage dependent potassium channels

    David Eliezer, Biochemistry, Weill Med College
    Structural properties of the Alzheimer’s disease protein tau

    Bob Callender, Biochem, Einstein College of Medicine
    Contribution of atomic and molecular motion to enzymatic catalysis

    Deepak Nair (Aggarwal Lab), Physiol & Biophys, Mt. Sinai
    Structural basis of lesion bypass by DNA polymerase iota and REV1

    Marta Filizola, Physiol & Biophys, Weill Med College
    Structural models and dynamics of GPCR oligomers

    Richard Gillilan, MacCHESS, Cornell University
    New opportunities with Cornell’s Energy Recovery Linac

    Kakoli Mitra (Frank Lab), Comp Biol & Mol Imaging, Wadsworth Ctr
    Structure of E. coli protein-conducting channel bound to translating ribosome

    Seth Darst, Molecular Biophys, Rockefeller University
    Structural basis for transcription-coupled DNA repair in bacteria


    2005 Summer Session, Cold Spring Harbor Lab, August 10, 2005

    Chris Lima, Memorial Sloan Kettering Cancer Center
      Insights into E3 ligase activity and SUMO conjugation

    Junjie Hu, NYU School of Medicine
    Structural Basis for phosphotyrosine recognition by the SH2 domains of SH2B and APS

    Brajesh K. Rai, Fisher Lab, Albert Einstein College of Medicine
    Multiple Mapping Method: A novel approach to the sequence-to-structure alignment problem in comparative protein structure modeling

    Caroline Kisker, Stony Brook University
     How does it cut? Insights into the incision reactions during nucleotide excision repair

    Ned Seeman, New York University
    DNA: Not Merely the Secret of Life

     Corey Mandel, Tong Lab, Columbia University
    Trials and tribulations in the structure determination of CPSF 100

     Steve Dierker, National Synchrotron Light Source, Brookhaven Laboratory
     NSLS-II: The Future National Synchrotron Light Source

    Eric Greene, Columbia University
    Slip sliding away: visualizing one-dimensional diffusion of proteins on DNA

     Joe Marcotrigiano, Rice Lab, Rockefeller University
    The hepatitis C virus autoprotease is a dimeric cysteine protease with a composite active site

    Allan Simpson, GE Healthcare Sweden
    Increasing Throughput in Protein Purification

    Robert Spencer & Brian McKeever, Merck Research Labs
    Exploring Membrane Protein Structure at Merck

    Wayne Hendrickson, Columbia University P&S
    Follicle Stimulation Hormone(FSH) stimulation of its receptor


    Fiftysecond Meeting, April 20, 2005

    Benoit Roux, Weill Medical College of Cornell University:
      Selectivity of the K+ Channel: The Importance of Protein Flexibility

    Moosa Mohammadi, NYU School of Medicine
    Structural Basis for FGF Receptor Activation: Implications in Development and Disease

    John Berriman, New York Structural Biology Center
    Molecular Portraits by Cryo-EM: Old Puzzles in Rotavirus


    Fiftyfirst Meeting. February 23, 2005

    Steve Hubbard,New York University:
    Structural studies of MuSK receptor tyrosine kinase

    Aneel Aggarwal, Mount Sinai School of Medicine:

    David Wah, Public Health Research Institute:
    A Substrate-Delivery System for an Energy-Dependent Proteolytic Machine


    Fiftieth Meeting. December 15, 2004

    Hermann Schindelin, Stony Brook University:
    Gephyrin - A bridge between molybdenum cofactor biosynthesis and neuroreceptor anchoring

    Milton Werner, Rockefeller University:
    In search of the mechanism of transcriptional transactivation

    Scott Strobel, Yale University:
    Crystal structure of a group I intron splicing intermediate


    Fortyninth Meeting. October 6, 2004

    Xiang-Peng Kong, Skirball Institute, NYU School of Medicine:
    CryoEM studies of bladder epithelial membrane plaques: structural and functional implications

    Hernando Sosa, Albert Einstein College of Medicine:
    Configuration of the Kinesin-Microtubule Interaction as Seen by Fluorescence Polarization Microscopy

    Qiu-Xing Jiang, Rockefeller University:
    Single particle analysis of a voltage-gated potassium channel KvAP in an open conformation


    Fortyeighth Meeting. April 7, 2004

    Dinshaw Patel, Memorial Sloan-Kettering Cancer Center:
    Protein-RNA Recognition Events in RNA Interference

    Caroline Kisker, Stony Brook University:
    Lesion (in)tolerance reveals insights into DNA replication fidelity

    Roberto Sanchez, Mount Sinai School of Medicine:
    How good/bad are comparative models of protein structure?


    Fortyseventh Meeting. February 4, 2004

    Kathy Borden, Mount Sinai School of Medicine:
    Accidental Drug Discovery: The antiviral Ribavirin directly inhibits eIF4E through physical mimicry of the m7Gcap

    David Stokes, Skirball Institute, New York University School of Medicine:
    Electron tomography of desmosomes

    Bradford Graves, Hoffman - La Roche, Inc.:
    If at first you don't succeed ...: The binding of small molecule antagonists to Mdm2


    Fortysixth Meeting. December 3, 2003

    Aneel Aggarwal, Mount Sinai School of Medicine:
    SAM I am: A new RNA Binding Motif

    Ming-Ming Zhou, Mount Sinai School of Medicine:
    Probing the Molecular Mechanisms of the RNA-induced Silencing Pathway

    Leemor Joshua-Tor, Cold Spring Harbor Laboratory:
    The PAZ domain of Argonaute2: siRNAs at RISC


    Fortyfifth Meeting. October 1, 2003

    Lawrence Shapiro, Columbia University:
    Adipocyte-secreted hormones modulate insulin action

    Marilyn Gunner, City College:

    Ruth Stark, CUNY College of Staten Island:
    NMR studies of Molecular Structure and Dynamics in Fatty Acid-Binding Proteins


    Fortyfourth Meeting. May 28, 2003

    Mark Chance, Albert Einstein Center for Synchrotron Biosciences:
    Visualizing the Ca+2 Dependent Activation of Gelsolin Using Synchrotron Footprinting

    Erec Stebbins, Rockefeller University:
    Manipulation of the Host Cytoskeleton by SipA of Salmonella

    Clay Bracken, Weill Medical College of Cornell University:
    NMR studies of helix formation and the unfolded state


    Fortythird Meeting. March 26, 2003

    Milton Werner,Rockefeller University:
    Rethinking the activation mechanism of tumor necrosis factor death receptors
    John Hunt, Columbia University:
    Structural mechanics of the SecA translocation ATPase and the 'A-protein' paradigm
    Benoit Roux, Weill Medical College of Cornell University:
    Theoretical and Computational Models of Ion Channels


    Fortysecond Meeting. February 12, 2003

    Chris Lima,Weill Medical College of Cornell University:
    Capping mRNA, structural insights into co-transcriptional mRNA processing
    Stephen Burley, Structural Genomix:
    Structure-based discovery of human protein kinase inhibitors
    Themis Lazaridis, City College of New York:
    Modeling membrane proteins in an implicit membrane


    Fortyfirst Meeting. November 6, 2002

    Eric Gouaux, Columbia University:
    Mechanisms for activation and desensitization of glutamate receptors
    Andy Neuwald, Cold Spring Harbor Laboratory:
    Canonical Ras, Rab, Rho and Ran GTPase structural features and Ran's Cterminal and basic patch mechanism
    Rui-Ming Xu, Cold Spring Harbor Laboratory:
    Structural studies of transcription silencing


    Fortieth Meeting. May 29, 2002

    Fred Hughson, Princeton University:
    Structural identification of a bacterial quorum-sensing signal containing boron
    Mark Girvin, Albert Einstein College of Medicine:
    Solution NMR of membrane proteins
    Carlos Simmerling, SUNY Stonybrook:
    Simulation of biomolecular structure and dynamics on large clusters of personal computers


    Thirtyninth Meeting. March 6, 2002

    Yigong Shi, Princeton University
    Structural mechanism of Apaf-1-mediated apoptosis
    Diana Murray, Weil Medical College, Cornell University
    Electrostatic regulation of protein-membrane interactions in subcellular
    targeting: Insights from computational analysis

    Stephen Burley, Rockefeller University and Structural GenomiX
    X-ray structure of the NC2-TBP-DNA ternary complex


    Thirtyeighth Meeting. January 10, 2002

    An-Suei Yang, Columbia University
    Local sequence codes for protein structures
    Hermann Schindelin, SUNY Stony Brook
    Mechanistic insights into ubiquitin activation from the crystal structure of
    a bacterial MoeB-MoaD complex

    Dimitar Nikolov, Sloan-Kettering Institute
    Structure of an Eph receptor/ephrin complex


    Thirtyseventh Meeting. November 28, 2001

    Benoit Roux, Weill Medical College of Cornell University
    Michael Becker, Brookhaven National Laboratory
    Christopher Lima, Weill Medical College of Cornell University


    Thirtysixth Meeting. October 3, 2001

    Barry Honig, Columbia University
    Ming-Ming Zhou, Mount Sinai School of Medicine
    Leemor Joshua-Tor, Cold Spring Harbor Laboratory


    Thirtyfifth Meeting. May 30, 2001

    Nick Tonks, Cold Spring Harbor Laboratory
    From Structure to Function of Protein Tyrosine Phosphatases
    Marilyn Gunner, City University of New York
    Motifs for Stabilizing Charges in Proteins
    Seth Darst, The Rockefeller University
    Structural Studies of Prokaryotic Transcription


    Thirtyfourth Meeting. March 7, 2001

    Min Lu, Weill Medical College of Cornell University
    HIV-1 Membrane Fusion and its Inhibition
    Kathy Borden, Mount Sinai School of Medicine
    Structure, Function of PHD fingers: Does this have a familiar RING?
    Hao Wu, Weill Medical College of Cornell University
    Structural Studies of Caspase Inhibition


    Thirtythird Meeting. January 8, 2001

    Dimitar Nikolov, Sloan Kettering Institute
    Structural Studies of a Nucleotidylyltransferase as a Tool for in vitro Combinatorial Biosynthesis of Libraries
    Joachim Frank, The Wadsworth Center
    The Ribosome in Motion - Conformational Changes Observed by Three-Dimensional Cryo-EM
    Stephen Burley, The Rockefeller University
    Structural Genomics of Cholesterol Biosynthesis


    Thirtysecond Meeting. November 29, 2000

    Steven Smith, SUNY Stony Brook
    Internal Packing of Helical Membrane Proteins
    Burkhard Rost, Columbia University
    John Kuriyan, Rockefeller University
    Structural Analysis of DNA Polymerase Clamp Loading


    Thirtyfirst Meeting. September 27, 2000

    Barry Honig, Columbia University
    Combining bioinformatics and biophysics to predict protein structure and function
    Daniel Wyss, Schering Plough Research Institute
    Structure and dynamics of the hepatitis C virus protease and helicase
    Liang Tong, Columbia University
    Structural basis of signal transduction by toll/IL1-R domains


    Thirtieth Meeting. May 17, 2000

    MICHAEL ROSEN, Sloan-Kettering Cancer Institute
    Regulation of the Wiskott-Aldrich Syndrome Protein
    STEVAN HUBBARD, NYU Medical Center
    Structural Basis of Fibroblast Growth Factor Receptor Activation
    Molecular Dynamics Analysis of DNA TATA-box variants


    Twentyninth Meeting. March 22, 2000

    ANN McDERMOTT, Columbia University
    NMR studies of biomolecules
    LARRY SHAPIRO, Mount Sinai
    Structure and function of the obesity-related protein, tubby
    CHRIS LIMA, Weill Medical College of Cornell University
    Proteolytic regulation in the SUMO/Smt3 pathway


    Twentyeighth Meeting. January 19, 2000

    MARK GIRVIN, Albert Einstein College of Medicine
    How Proton Translocation Drives Rotation in the ATP Synthase
    ANNA MARIE PYLE, Columbia University
    A kinetic and structural framework for helicase activity in the DexH/D proteins
    STEWART SHUMAN, Sloan-Kettering Institute
    Structure and mechanism of the mRNA capping apparatus


    Twentyseventh Meeting. December 1, 1999

    Seth Darst, Rockefeller University:
    Title to be arranged
    Caroline Kisker, SUNY, Stony Brook
    Crystal structure of UvrB provides insight into the mechanism of nucleotide excision repair
    David Beveridge, Wesleyan University
    Title to be arranged


    Twentysixth Meeting. September 29, 1999

    Terry Gaasterland, Rockefeller University:
    Comparative Genomics
    Ming-Ming Zhou, Mount Sinai School of Medicine:
    Protein-Protein Interactions in Chromatin Remodeling
    Dinshaw Patel, Sloan-Kettering Institute:
    Adaptive Recognition by Nucleic Acid Aptamers


    Twentyfifth Meeting. May 19, 1999

    Mike Rosen (Sloan-Kettering Institute)
    Aneel Aggarwal (Mt. Sinai School of Medicine)
    Gaetano Montelione (Rutgers University)


    Twentyfourth Meeting. March 24, 1999

    Andrej Sali (Rockefeller University)
    Hao Wu (Cornell University Medical College)
    Ned Seeman (New York University)


    Twentythird Meeting. January 20, 1999

    Eric Gouaux (Columbia University)
    Burkhard Rost (Columbia University)
    Milton Werner (Rockefeller University)


    Twentysecond Meeting. November 11, 1998

    Rich Friesner (Columbia University)
    Axel Br√ľnger (Yale University)
    Thierry Fischmann (Schering-Plough Research Institute)


    Twentyfirst Meeting. September 9, 1998

    Rod Mackinnon, Rockefeller University
    Art Palmer, Columbia University
    Maria-Luisa Tasayco, City College

    Twentieth Meeting. May 27, 1998.

    Tamar Schlick, NYU
    Elena Conti, Rockefeller University (Kuriyan Lab)
    Steve Almo , Albert Einstein College of Medicine

    Nineteenth Meeting. March 25, 1998.

    Yale Evening:
    Mark Gerstein
    Andrew Miranker
    Paul Sigler

    Eighteenth Meeting. January 7, 1998.

    David Stokes, NYU Medical Center
    Tom Sakmar, Rockefeller
    Wayne Hendrickson, Columbia University

    Seventeenth Meeting. November 5, 1997.

    Stevan Hubbard, NYU Medical Center
    Dinshaw Patel, Sloan-Kettering Institute
    Ann McDermott, Columbia University

    Sixteenth Meeting. September 24, 1997.

    Stephen Burley, Rockefeller University
    Barry Honig, Columbia University
    Dixie Goss, Hunter College


    Seventh Meeting. November 29, 1995.

    Stephen Burley, Rockefeller University
    Marilyn Gunner, City College, CUNY
    Art Palmer, Columbia University

    Sixth Meeting. September 27, 1995.

    Nikola Pavletich, Sloan-Kettering Institute
    Bob Callender, City College, CUNY
    Barry Honig, Columbia University

    Fifth Meeting. May 17, 1995.

    Paula Fitzgerald, Merck Research Labs
    Harel Weinstein, Mt. Sinai School of Medicine

    Fourth Meeting. March 8, 1995.

    Ann McDermott, Columbia University
    Andrej Sali, Rockefeller University
    Stephen Burley, Rockefeller University

    Third Meeting. January 11, 1995.

    Ruben Abagyan, NYU Medical Center
    Wayne Hendrickson, Columbia University
    Dinshaw Patel, Sloan-Kettering Institute

    Second Meeting. November 15, 1994.

    Rich Friesner, Columbia University
    Ned Seeman, New York University
    Giovanna Scapin, Albert Einstein College of Medicine

    First Meeting. September 28, 1994.

    Anthony Nicholls, Columbia University
    Nikola Pavletich, Sloan-Kettering Institute
    Brian Chait, Rockefeller University